rs3738414

A SNP in the VTCN1 gene on chromosome 1. Its most notable genotype is A;A: 0.4x decreased risk of breast cancer

Gene
VTCN1
Location
Chr 1117,210,906 (GRCh38)
Highest magnitude
1.6Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
9%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGood0.4x decreased risk of breast cancerMinor · 1.64% of people
  2. A;GNot ratednormalTypical · 0.018% of people
  3. G;GNot ratednormalTypical · 0.078% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 7 HapMap populations.

  • AverageA;A 4% A;G 18% G;G 78%
  • European ancestry (Utah)A;A 0% A;G 2% G;G 98%
  • Han Chinese (Beijing)A;A 7% A;G 37% G;G 56%
  • Japanese (Tokyo)A;A 12% A;G 35% G;G 52%
  • Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
  • Chinese (Denver)A;A 9% A;G 40% G;G 51%
  • Mexican ancestry (Los Angeles)A;A 0% A;G 7% G;G 93%
  • TuscanA;A 0% A;G 2% G;G 98%

Conditions, medicines and genes

Other VTCN1 SNPs

All VTCN1 SNPs

Notes

From SNPedia

Notes

rs3738414 is a SNP in the V-set domain containing T cell activation inhibitor 1 VTCN1 gene, which is also known as B7-H4. A study of 500 Chinese Han women with breast cancer (and an equal number of matched controls) concluded that the rs3738414(A;A) genotype showed a significantly decreased risk of breast cancer (odds ratio 0.412, CI: 0.203-0.835).

Source and license

Adapted from rs3738414 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.