rs10895068

A SNP in the PGR gene on chromosome 11. Its most notable genotype is T;T: 2.5x increased odds of breast cancer among hormone-using postmenopausal women

Gene
PGR
Location
Chr 11101,129,483 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
2%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad2.5x increased odds of breast cancer among hormone-using postmenopausal womenMinor · 1.512% of people
  2. C;TBad2.5x increased odds of breast cancer among hormone-using postmenopausal womenMinor · 1.588% of people
  3. C;CGoodnormalTypical · 0.00% of people

SNPedia records rs10895068 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in one HapMap population.

  • European ancestry (Utah)T;T 12% C;T 88% C;C 0%

Conditions, medicines and genes

Other PGR SNPs

All PGR SNPs

Notes

From SNPedia

Show notes, about 190 words

rs10895068, also known as +331G/A, is a SNP in the progesterone receptor PGR gene. A study of 1,664 postmenopausal breast cancer cases and 2,391 controls led to two conclusions. First, women with at least one rs10895068(A) allele had a 1.3x (CI: 1.04-1.65) increased risk of developing breast cancer. Second, such carriers were at 2.57x (CI: 1.64-4.02) increased risk for breast cancer if they were never postmenopausal hormone users. 2013 meta-analysis suggested association of weak effect with female reproductive (breast, endometrial and ovarian) cancer for A allele (A: OR = 1.063, 95% CI = 1.001-1.129; AA+AG: OR = 1.067, 95% CI = 1.002-1.136). A 2014 meta-analysis that looked only for association with ovarian cancer specifically found no significant association between rs10895068 and ovarian cancer - despite the study title claiming otherwise. Progesterone receptor PROGINS and +331G/A polymorphisms confer susceptibility to ovarian cancer: a meta-analysis based on 17 studies. Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: evidence from a meta-analysis.

Source and license

Adapted from rs10895068 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.