rs111033258

A SNP in the CLRN1 gene on chromosome 3. Its most notable genotype is C;C: Usher syndrome Type III

Gene
CLRN1
Location
Chr 3150,972,565 (GRCh38)
Highest magnitude
5.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableBadUsher syndrome Type IIIVery important · 5.0
  2. A;CBadcarrier of Usher syndrome Type III alleleImportant · 3.0
  3. A;AGoodcommon in clinvarTypical · 0.0

SNPedia records rs111033258 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other CLRN1 SNPs

All CLRN1 SNPs

Notes

From SNPedia

Notes

rs111033258, also known as N48K or Asn48Lys, is a SNP in the clarin 1 CLRN1 gene on chromosome 3. Most common in Ashkenazi Jews, the risk allele rs111033258(G) leads to Usher Syndrome Type III if inherited in two copies. Note that in 23andMe, the orientation is reversed from dbSNP, so the risk allele for the equivalent SNP, i4990151, is (C).

Source and license

Adapted from rs111033258 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.