rs1142345(C;C)

Possibly incapable of detoxifying certain drugs

Magnitude
3.5Important
Repute
Bad
Frequency
<1%Average of 11 populations
On SNPedia
rs1142345(G;G)Minus strand
Gene
TPMT

Frequency

Share of people with C;C in each HapMap population.

  • Mexican ancestry (Los Angeles)3%
  • Luhya (Kenya)2%
  • European ancestry (Utah)0%
  • Han Chinese (Beijing)0%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%
  • African ancestry (Southwest US)0%
  • Chinese (Denver)0%
  • Gujarati Indian0%
  • Maasai (Kenya)0%
  • Tuscan0%

Other genotypes of rs1142345

  1. T;TGoodcommon in clinvarTypical · 0.092% of people
  2. C;TBadTPMT*3C . impaired drug metabolismImportant · 3.08% of people

All about rs1142345

Notes

From SNPedia

poor drug metabolism of some medications. potentially encoding a variant incapable of detoxifying byproducts of certain antineoplastic and immunosuppressant drugs. http://blog.23andme.com/health-traits/do-you-know-how-youll-respond-to-thiopurine-medications/

Source and license

Adapted from rs1142345(G;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.