rs1142345(C;T)

TPMT*3C . impaired drug metabolism

Magnitude
3.0Important
Repute
Bad
Frequency
8%Average of 11 populations
On SNPedia
rs1142345(A;G)Minus strand
Gene
TPMT

Frequency

Share of people with C;T in each HapMap population.

  • Luhya (Kenya)19%
  • African ancestry (Southwest US)16%
  • Mexican ancestry (Los Angeles)10%
  • Yoruba (Nigeria)8%
  • Chinese (Denver)6%
  • European ancestry (Utah)5%
  • Japanese (Tokyo)5%
  • Gujarati Indian5%
  • Maasai (Kenya)5%
  • Tuscan3%
  • Han Chinese (Beijing)2%

Other genotypes of rs1142345

  1. T;TGoodcommon in clinvarTypical · 0.092% of people
  2. C;CMost notableBadpossibly incapable of detoxifying certain drugsImportant · 3.5<1% of people

All about rs1142345

Source and license

Adapted from rs1142345(A;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.