rs1143679

A SNP in the ITGAM gene on chromosome 16. Its most notable genotype is A;A: >1.78x increased risk for SLE

Gene
ITGAM
Location
Chr 1631,265,490 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
9%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad>1.78x increased risk for SLEImportant · 3.0
  2. A;GBad1.78x increased risk for SLEWorth knowing · 2.4
  3. G;GGoodnormalTypical · 0.0

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other ITGAM SNPs

All ITGAM SNPs

Notes

From SNPedia

Notes

Causal SNP in the ITGAM (CD11b) gene in patients with SLE who are of European or African descent;(P = 1.7 x 10(-17), odds ratio = 1.78). reconfirmed

Source and license

Adapted from rs1143679 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.