rs121908415

A SNP in the ACTN4 gene on chromosome 19. Its most notable genotype is A;G: Focal segmental glomerulosclerosis 1 (possible)

Gene
ACTN4
Location
Chr 1938,710,286 (GRCh38)
Highest magnitude
3.5Important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon in clinvarTypical · 0.0
  2. A;GMost notableBadFocal segmental glomerulosclerosis 1 (possible)Important · 3.5

On SNPedia: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other ACTN4 SNPs

All ACTN4 SNPs

Notes

From SNPedia

Notes

Focal segmental glomerulosclerosis Called i5900585 by 23andMe

A;G

Reported in some individuals - but not others - to lead to focal segmental glomerulosclerosis 1. See OMIM entry linked to rs121908415.

Source and license

Adapted from rs121908415 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.