rs121908417

A SNP in the ACTN4 gene on chromosome 19. Its most notable genotype is C;T: Focal segmental glomerulosclerosis 1 (possible)

Gene
ACTN4
Location
Chr 1938,710,307 (GRCh38)
Highest magnitude
3.5Important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;TMost notableBadFocal segmental glomerulosclerosis 1 (possible)Important · 3.5
  2. T;TGoodcommon in clinvarTypical · 0.0

On SNPedia: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other ACTN4 SNPs

All ACTN4 SNPs

Notes

From SNPedia

Notes

Focal segmental glomerulosclerosis Called i5900587 by 23andMe

C;T

Reported in some individuals to lead to focal segmental glomerulosclerosis 1. See OMIM entry linked to rs121908417.

Source and license

Adapted from rs121908417 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.