rs121908805
A SNP in the CFTR gene on chromosome 7. Its most notable genotype is A;C: carrier of a cystic fibrosis allele
- Gene
- CFTR
- Location
- Chr 7117,559,468 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;CMost notableBadcarrier of a cystic fibrosis allele
- C;CGoodcommon in clinvar
- C;GBadcarrier of a cystic fibrosis allele
On SNPedia: (A;C), (C;C), (C;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CFTR SNPs
- i4000292D;Dcystic fibrosisVery important
- rs74551128A;ACystic fibrosisVery important
- rs113993960-;-Cystic Fibrosis; homozygote for delta F-508 mutationVery important
- rs199826652-;-Cystic Fibrosis; homozygote for delta F-508 mutationVery important
- i4000309A;ACystic FibrosisVery important
- i4000294A;ACystic FibrosisVery important
- i4000296T;TCystic FibrosisVery important
- i4000297A;ACystic FibrosisVery important
Notes
From SNPedia
Notes
Cystic fibrosis; c.1397C>A or c.1397C>G, p.Ser466Ter named i5011223 or i5011224 by 23andMe Three novel mutations (I506S, S466X, 1651A-->T) in exon 10 of the cystic fibrosis transmembrane conductance regulator (CFTR) detected in patients of southern German descent.
A;C
Cystic fibrosis mutation carrier; unaffected unless CF mutation present on other copy of CF gene
C;G
Cystic fibrosis mutation carrier; unaffected unless CF mutation present on other copy of CF gene
Source and license
Adapted from rs121908805 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.