rs121908916

A SNP in the SCN9A gene on chromosome 2. Its most notable genotype is A;A: Congenital insensitivity to pain

Gene
SCN9A
Location
Chr 2166,303,162 (GRCh38)
Highest magnitude
4.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.0
  2. A;GBadcarrier of one allele for insensitivity to painImportant · 3.0
  3. A;AMost notableBadCongenital insensitivity to painVery important · 4.0

SNPedia records rs121908916 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other SCN9A SNPs

All SCN9A SNPs

Notes

From SNPedia

Notes

rs121908916, also known as c.829C>T, p.Arg277Ter and R277X, is a rare mutation in the SCN9A gene on chromosome 2. Inherited in a recessive manner, the homozygous minor genotype for this SNP is reported to result in insensitivity to pain.

A;G

see discussion at rs121908916

A;A

see discussion at rs121908916

Source and license

Adapted from rs121908916 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.