rs121912651
A SNP in the TP53 gene on chromosome 17. Its most notable genotype is C;G: Li-Fraumeni Syndrome (predicted)
- Gene
- TP53
- Location
- Chr 177,674,221 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- C;GMost notableBadLi-Fraumeni Syndrome (predicted)
- A;GBadLi-Fraumeni Syndrome (predicted)
SNPedia records rs121912651 on the minus strand: (C;C), (C;G), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other TP53 SNPs
- rs28934578T;Tinfo@snpedia.com would like to hear from youVery important
- rs11540652C;TLi-Fraumeni Syndrome (predicted)Very important
- rs11575997C;TLi-Fraumeni Syndrome (predicted)Very important
- rs28934573C;GLi-Fraumeni Syndrome (predicted)Very important
- rs28934574C;GLi-Fraumeni Syndrome (predicted)Very important
- rs28934575C;TLi-Fraumeni Syndrome (predicted)Very important
- rs28934576C;TLi-Fraumeni Syndrome (predicted)Very important
- rs28934577A;CLi-Fraumeni Syndrome (predicted)Very important
Notes
From SNPedia
Notes
aka c.742C>T (p.Arg248Trp or R248W) The TP53 p.R248W variant is a highly recurrent somatic mutation while also reported as a germline variant in both pediatric rhabdomyosarcoma () and gliomas, according to . 23andMe name: i5048835
Source and license
Adapted from rs121912651 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.