rs121918251
A SNP in the MUT gene on chromosome 6. Its most notable genotype is T;T: Methylmalonic aciduria (predicted)
- Gene
- MUT
- Location
- Chr 649,459,189 (GRCh38)
- Highest magnitude
- 8.8Very important
- Tested on
- AncestryDNA
- Minor allele frequency
- <1%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableBadMethylmalonic aciduria (predicted)
- C;TBadCarrier for a methylmalonic aciduria mutation
- C;CGoodcommon in clinvar
SNPedia records rs121918251 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MUT SNPs
- rs121918248A;AMethylmalonic aciduria (predicted)Very important
- rs121918249G;GMethylmalonic aciduria (predicted)Very important
- rs121918252A;AMethylmalonic aciduria (predicted)Very important
- rs121918253A;AMethylmalonic aciduria (predicted)Very important
- rs121918254T;TMethylmalonic aciduria (predicted)Very important
- rs121918256A;AMethylmalonic aciduria (predicted)Very important
- rs121918257A;AMethylmalonic aciduria (predicted)Very important
- rs121918258T;TMethylmalonic aciduria (predicted)Very important
Notes
From SNPedia
Notes
aka c.278G>A, p.Arg93His or R93H 23andMe name: i5007472
C;T
See details via ClinVar link on main SNP/rs# page.
Source and license
Adapted from rs121918251 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.