rs121918257

A SNP in the MUT gene on chromosome 6. Its most notable genotype is A;A: Methylmalonic aciduria (predicted)

Gene
MUT
Location
Chr 649,459,145 (GRCh38)
Highest magnitude
8.8Very important
Tested on
AncestryDNA
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.0
  2. A;GBadCarrier for a methylmalonic aciduria mutationImportant · 3.0
  3. A;AMost notableBadMethylmalonic aciduria (predicted)Very important · 8.8

SNPedia records rs121918257 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other MUT SNPs

All MUT SNPs

Notes

From SNPedia

Notes

aka c.322C>T, p.Arg108Cys or R108C; common pathogenic variant among Hispanics 23andMe name: i5000073

A;G

See details via ClinVar link on main SNP/rs# page.

Source and license

Adapted from rs121918257 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.