rs121918385
A SNP in the APOB gene on chromosome 2. Its most notable genotype is -;C: Carrier of a hypobetalipoproteinemia mutation
- Gene
- APOB
- Location
- Chr 221,003,241 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- -;CMost notableBadCarrier of a hypobetalipoproteinemia mutation
- C;CGoodcommon in clinvar
SNPedia records rs121918385 on the minus strand: (-;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other APOB SNPs
- i4000339A;AFamilial Hypercholesterolemia Type BVery important
- rs5742904A;CFamilial HypercholesterolemiaVery important
- rs144467873A;Afamilial hypercholesterolemiaVery important
- rs730880052G;TFamilial HypercholesterolemiaVery important
- rs886039829-;THypercholesterolemia, Type B; heterozygoteImportant
- rs12713559A;Gcarrier of possible familial hypercholesterolemia mutationImportant
- rs121918383A;GCarrier of a hypobetalipoproteinemia mutationImportant
- rs121918384-;GTCarrier of a hypobetalipoproteinemia mutationImportant
Notes
From SNPedia
Notes
-;C
Mostly unaffected in absence of a second APOB mutation
Source and license
Adapted from rs121918385 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.