rs144467873
A SNP in the APOB gene on chromosome 2. Its most notable genotype is A;A: familial hypercholesterolemia
- Gene
- APOB
- Location
- Chr 221,006,289 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadfamilial hypercholesterolemia
- A;GBadcarrier of familial hypercholesterolemia mutation
- G;GGoodcommon/normal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other APOB SNPs
- i4000339A;AFamilial Hypercholesterolemia Type BVery important
- rs5742904A;CFamilial HypercholesterolemiaVery important
- rs730880052G;TFamilial HypercholesterolemiaVery important
- rs886039829-;THypercholesterolemia, Type B; heterozygoteImportant
- rs12713559A;Gcarrier of possible familial hypercholesterolemia mutationImportant
- rs121918383A;GCarrier of a hypobetalipoproteinemia mutationImportant
- rs121918384-;GTCarrier of a hypobetalipoproteinemia mutationImportant
- rs121918385-;CCarrier of a hypobetalipoproteinemia mutationImportant
Notes
From SNPedia
Notes
rs144467873, also known as R3500W, is a SNP in the APOB apolipoprotein B gene. The risk allele is A according to 23andMe, which tests for this SNP in regard to familial hypercholesterolemia type B under the name i4000339. This SNP is found mainly in Asian populations.
Source and license
Adapted from rs144467873 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.