rs121965065

A SNP in the F11-AS1 gene on chromosome 4. Its most notable genotype is G;G: Factor XI deficiency

Gene
F11-AS1
Location
Chr 4186,285,711 (GRCh38)
Highest magnitude
5.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBadFactor XI deficiencyVery important · 5.0
  2. G;TBadcarrier of factor XI mutationImportant · 3.0
  3. T;TGoodcommon in clinvarTypical · 0.0

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other F11-AS1 SNPs

All F11-AS1 SNPs

Notes

From SNPedia

Notes

aka c.1378T>G (p.Phe460Val) 23andMe name: i5001640

G;T

Usually not affected in absence of a second F11 gene mutation

Source and license

Adapted from rs121965065 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.