rs373297713

A SNP in the F11-AS1 gene on chromosome 4. Its most notable genotype is A;A: Factor XI deficiency

Gene
F11-AS1
Location
Chr 4186,287,824 (GRCh38)
Highest magnitude
5.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadFactor XI deficiencyVery important · 5.0
  2. A;GBadcarrier of factor XI mutationImportant · 3.0
  3. G;GGoodcommon/normalTypical · 0.0

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other F11-AS1 SNPs

All F11-AS1 SNPs

Notes

From SNPedia

Notes

rs373297713, better known as c.1716+1G>A or IVS14DS, G-A, +1, is a SNP in the coagulation factor XI F11 gene. This SNP is reported by 23andMe as one of the three most common factor XI deficiency-causing mutations found in Ashkenazi Jews; it is termed i4000397 by 23andMe. See OMIM 264900.0001

A;G

Usually not affected in absence of a second F11 gene mutation

Source and license

Adapted from rs373297713 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.