rs12531711
A SNP in the TNPO3 gene on chromosome 7. Its most notable genotype is A;A: common in complete genomics
- Gene
- TNPO3
- Location
- Chr 7128,977,412 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 5%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageA;A 89%
- European ancestry (Utah)A;A 77%
- Han Chinese (Beijing)A;A 99%
- Japanese (Tokyo)A;A 100%
- Yoruba (Nigeria)A;A 100%
- African ancestry (Southwest US)A;A 98%
- Gujarati IndianA;A 71%
- Luhya (Kenya)A;A 98%
- Mexican ancestry (Los Angeles)A;A 69%
- Maasai (Kenya)A;A 92%
- TuscanA;A 84%
Related
Conditions, medicines and genes
Other TNPO3 SNPs
- rs587777430-;AMuscular dystrophy type 1F and also HIV-1 infection resistanceVery important
- rs10488631C;C2x increased risk of developing SLE; 3.2x increased risk of developing primary biliary cirrhosis; and 3.4x increased risk of developing Sjögren's syndromeImportant
- rs2280714T;T1.4x increased risk of SLEMinor
Notes
From SNPedia
Notes
association with lupus risk allele is (G), odds ratio 1.95 (CI: 1.68-2.25, p = 2.710e-18)
Source and license
Adapted from rs12531711 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.