rs587777430

A SNP in the TNPO3 gene on chromosome 7. Its most notable genotype is -;A: Muscular dystrophy type 1F and also HIV-1 infection resistance

Gene
TNPO3
Location
Chr 7128,957,256 (GRCh38)
Highest magnitude
6.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. -;AMost notableNot ratedMuscular dystrophy type 1F and also HIV-1 infection resistanceVery important · 6.0
  2. T;TGoodcommon in clinvarTypical · 0.0
  3. AG;AGGoodcommon in clinvarTypical · 0.0
  4. I;IGoodcommon genotypeTypical · 0.0
  5. A;AGoodcommon in clinvarTypical · 0.0

SNPedia records rs587777430 on the minus strand: (-;T), (A;A), (AG;AG), (I;I), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other TNPO3 SNPs

All TNPO3 SNPs

Notes

From SNPedia

Notes

aka c.2771del or c.2771delA This mutation has been reported in several Spanish families as pathogenic for autosomal dominant limb-girdle muscular dystrophy type 1F.OMIM 610032.0001 In 2019, this mutation was also reported to confer strong resistance against HIV-1 infection.

-;A

see links via main rs-page

Source and license

Adapted from rs587777430 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.