rs12587
A SNP in the KRAS gene on chromosome 12. Its most notable genotype is T;T: common in clinvar
- Gene
- KRAS
- Location
- Chr 1225,205,894 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- Not on consumer chips
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs12587 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 24%
- European ancestry (Utah)T;T 25%
- Han Chinese (Beijing)T;T 6%
- Japanese (Tokyo)T;T 5%
- Yoruba (Nigeria)T;T 55%
- African ancestry (Southwest US)T;T 33%
- Chinese (Denver)T;T 5%
- Gujarati IndianT;T 16%
- Luhya (Kenya)T;T 48%
- Mexican ancestry (Los Angeles)T;T 22%
- Maasai (Kenya)T;T 40%
- TuscanT;T 13%
Related
Other KRAS SNPs
- rs104894359C;GNoonan syndromeVery important
- rs104894360A;TNoonan syndromeVery important
- rs104894361A;TNoonan syndromeVery important
- rs104894364A;GNoonan syndromeVery important
- rs104894365C;TNoonan syndromeVery important
- rs104894366C;GNoonan syndromeVery important
- rs727503110C;TNoonan syndromeVery important
- rs112445441A;CDrug response to cetuximab and panitumumabImportant
Source and license
Adapted from rs12587 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.