rs104894359
A SNP in the KRAS gene on chromosome 12. Its most notable genotype is C;G: Noonan syndrome
- Gene
- KRAS
- Location
- Chr 1225,227,346 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- Not on consumer chips
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;GMost notableBadNoonan syndrome
- C;CGoodcommon in clinvar
SNPedia records rs104894359 on the minus strand: (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other KRAS SNPs
- rs104894360A;TNoonan syndromeVery important
- rs104894361A;TNoonan syndromeVery important
- rs104894364A;GNoonan syndromeVery important
- rs104894365C;TNoonan syndromeVery important
- rs104894366C;GNoonan syndromeVery important
- rs727503110C;TNoonan syndromeVery important
- rs112445441A;CDrug response to cetuximab and panitumumabImportant
- rs712A;Acommon in clinvarTypical
Notes
From SNPedia
Notes
aka c.178G>C (p.Gly60Arg) 23andMe name: i6013759
C;G
see links via main rs-page
Source and license
Adapted from rs104894359 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.