rs112445441

A SNP in the KRAS gene on chromosome 12. Its most notable genotype is A;C: Drug response to cetuximab and panitumumab

Gene
KRAS
Location
Chr 1225,245,347 (GRCh38)
Highest magnitude
3.0Important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;CMost notableBadDrug response to cetuximab and panitumumabImportant · 3.0
  2. C;CGoodcommon in clinvarTypical · 0.0
  3. G;GGoodcommon in complete genomicsTypical · 0.0

On SNPedia: (A;C), (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other KRAS SNPs

All KRAS SNPs

Notes

From SNPedia

Notes

aka c.38G>T (p.Gly13Val) annotated in ClinVar as a somatic mutation, and also for its PGx association (drug response to cetuximab and panitumumab) 23andMe name for the c.38G>A variant: i5002724

A;C

see links on main rs-page, especially to PharmGKB via ClinVar

Source and license

Adapted from rs112445441 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.