rs12777823

A SNP in the LOC100130970 gene on chromosome 10. Its most notable genotype is A;A: Avoid Plavix, higher risk for adverse cardiovascular events. CYP2C19 poor metabolizer.

Gene
LOC100130970
Location
Chr 1094,645,745 (GRCh38)
Highest magnitude
3.5Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadAvoid Plavix, higher risk for adverse cardiovascular events. CYP2C19 poor metabolizer.Important · 3.56% of people
  2. A;GBadAvoid Plavix, higher risk for adverse cardiovascular events.Worth knowing · 2.534% of people
  3. G;GGoodcommon in clinvarTypical · 0.059% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 6% A;G 34% G;G 59%
  • European ancestry (Utah)A;A 2% A;G 25% G;G 74%
  • Han Chinese (Beijing)A;A 8% A;G 49% G;G 43%
  • Japanese (Tokyo)A;A 10% A;G 44% G;G 46%
  • Yoruba (Nigeria)A;A 8% A;G 41% G;G 52%
  • African ancestry (Southwest US)A;A 2% A;G 32% G;G 67%
  • Chinese (Denver)A;A 11% A;G 35% G;G 54%
  • Gujarati IndianA;A 15% A;G 33% G;G 53%
  • Luhya (Kenya)A;A 7% A;G 40% G;G 53%
  • Mexican ancestry (Los Angeles)A;A 2% A;G 24% G;G 74%
  • Maasai (Kenya)A;A 5% A;G 35% G;G 60%
  • TuscanA;A 1% A;G 19% G;G 80%

Conditions, medicines and genes

Notes

From SNPedia

Notes

JAMA rs12777823 and rs4244285 implicated in platelet response to clopidogrel

A;A

poor metabolizer of several popular medicines; Neighboring rs4244285 is a more reliable predictor, but this genotype is linked to being a poor metabolizer of several popular medicines; patients prescribed Plavix (Clopidogrel) have higher risk for adverse cardiovascular events.

A;G

Neighboring rs4244285 is a more reliable predictor, but this genotype is linked to being a poor metabolizer of several popular medicines; patients prescribed Plavix (Clopidogrel) have higher risk for adverse cardiovascular events.

Source and license

Adapted from rs12777823 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.