rs12777823(A;A)

Avoid Plavix, higher risk for adverse cardiovascular events. CYP2C19 poor metabolizer.

Magnitude
3.5Important
Repute
Bad
Frequency
6%Average of 11 populations
On SNPedia
rs12777823(A;A)
Gene
LOC100130970

Frequency

Share of people with A;A in each HapMap population.

  • Gujarati Indian15%
  • Chinese (Denver)11%
  • Japanese (Tokyo)10%
  • Han Chinese (Beijing)8%
  • Yoruba (Nigeria)8%
  • Luhya (Kenya)7%
  • Maasai (Kenya)5%
  • European ancestry (Utah)2%
  • African ancestry (Southwest US)2%
  • Mexican ancestry (Los Angeles)2%
  • Tuscan1%

Other genotypes of rs12777823

  1. A;GBadAvoid Plavix, higher risk for adverse cardiovascular events.Worth knowing · 2.534% of people
  2. G;GGoodcommon in clinvarTypical · 0.059% of people

All about rs12777823

Notes

From SNPedia

poor metabolizer of several popular medicines; Neighboring rs4244285 is a more reliable predictor, but this genotype is linked to being a poor metabolizer of several popular medicines; patients prescribed Plavix (Clopidogrel) have higher risk for adverse cardiovascular events.

Source and license

Adapted from rs12777823(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.