rs1360780

A SNP in the FKBP5 gene on chromosome 6. Its most notable genotype is T;T: 1.3x increased risk for depression

Gene
FKBP5
Location
Chr 635,639,794 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.047% of people
  2. C;TBad1.3x increased risk for depressionWorth knowing · 2.042% of people
  3. T;TMost notableBad1.3x increased risk for depressionWorth knowing · 2.111% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 47% C;T 42% T;T 11%
  • European ancestry (Utah)C;C 53% C;T 41% T;T 6%
  • Han Chinese (Beijing)C;C 56% C;T 39% T;T 4%
  • Japanese (Tokyo)C;C 62% C;T 35% T;T 4%
  • Yoruba (Nigeria)C;C 31% C;T 49% T;T 20%
  • African ancestry (Southwest US)C;C 27% C;T 55% T;T 18%
  • Chinese (Denver)C;C 59% C;T 31% T;T 10%
  • Gujarati IndianC;C 41% C;T 46% T;T 14%
  • Luhya (Kenya)C;C 46% C;T 39% T;T 15%
  • Mexican ancestry (Los Angeles)C;C 59% C;T 40% T;T 2%
  • Maasai (Kenya)C;C 37% C;T 48% T;T 15%
  • TuscanC;C 44% C;T 41% T;T 15%

Conditions, medicines and genes

Other FKBP5 SNPs

All FKBP5 SNPs

Notes

From SNPedia

Notes

In Caucasian non-Hispanics, the rs1360780(T) allele is associated with increased risk for depression, with an odds ratio of 1.39 (CI: 1.14-1.70, p=0.046). This same SNP, which is in the FKBP5 gene, may influence how patients respond to antidepressants including citalopram. rs1360780(T;T) homozgyotes tend to report more depressive episodes, but they also respond better to treatment with antidepressants. rs9296158 rs3800373 rs1360780 rs9470080 linked with the severity of child abuse to predict level of adult PTSD symptoms after correcting for multiple testing.

Source and license

Adapted from rs1360780 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.