rs7757037

A SNP in the FKBP5 gene on chromosome 6. Its most notable genotype is A;A: 0.63x decreased risk for bipolar disorder

Gene
FKBP5
Location
Chr 635,580,459 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
50%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGood0.63x decreased risk for bipolar disorderTypical · 0.024% of people
  2. A;GGood0.68x decreased risk for bipolar disorderTypical · 0.050% of people
  3. G;GNot ratednormalTypical · 0.026% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 24% A;G 50% G;G 26%
  • European ancestry (Utah)A;A 24% A;G 52% G;G 24%
  • Han Chinese (Beijing)A;A 31% A;G 54% G;G 15%
  • Japanese (Tokyo)A;A 37% A;G 49% G;G 14%
  • Yoruba (Nigeria)A;A 14% A;G 46% G;G 40%
  • African ancestry (Southwest US)A;A 9% A;G 51% G;G 40%
  • Chinese (Denver)A;A 43% A;G 40% G;G 17%
  • Gujarati IndianA;A 24% A;G 47% G;G 30%
  • Luhya (Kenya)A;A 17% A;G 50% G;G 33%
  • Mexican ancestry (Los Angeles)A;A 31% A;G 57% G;G 12%
  • Maasai (Kenya)A;A 13% A;G 48% G;G 39%
  • TuscanA;A 22% A;G 56% G;G 23%

Conditions, medicines and genes

Other FKBP5 SNPs

All FKBP5 SNPs

Notes

From SNPedia

Notes

rs7757037, a SNP in the FKBP5 gene, is associated with increased risk for bipolar disorder in a study of 500+ Caucasian patients. The most common allele, rs7757037(G), was associated with highest risk. Giving that allele a relative odds ratio of 1.0, the odds for the (A;G) and (A;A) genotypes were 0.68x (CI:0.53-0.87, p=0.007) and 0.63x (CI: 0.45-0.89, p=0.007).

Source and license

Adapted from rs7757037 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.