rs4713902

A SNP in the FKBP5 gene on chromosome 6. Its most notable genotype is C;C: 0.47x decreased risk for bipolar disorder

Gene
FKBP5
Location
Chr 635,646,249 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
24%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGood0.47x decreased risk for bipolar disorderTypical · 0.06% of people
  2. C;TGood0.69x decreased risk for bipolar disorderTypical · 0.032% of people
  3. T;TNot ratednormalTypical · 0.062% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 6% C;T 32% T;T 62%
  • European ancestry (Utah)C;C 6% C;T 37% T;T 57%
  • Han Chinese (Beijing)C;C 7% C;T 37% T;T 56%
  • Japanese (Tokyo)C;C 10% C;T 37% T;T 53%
  • Yoruba (Nigeria)C;C 0% C;T 13% T;T 87%
  • African ancestry (Southwest US)C;C 2% C;T 28% T;T 70%
  • Chinese (Denver)C;C 5% C;T 35% T;T 61%
  • Gujarati IndianC;C 2% C;T 31% T;T 67%
  • Luhya (Kenya)C;C 0% C;T 12% T;T 88%
  • Mexican ancestry (Los Angeles)C;C 19% C;T 59% T;T 22%
  • Maasai (Kenya)C;C 5% C;T 32% T;T 64%
  • TuscanC;C 12% C;T 36% T;T 52%

Conditions, medicines and genes

Other FKBP5 SNPs

All FKBP5 SNPs

Notes

From SNPedia

Notes

rs4713902, a SNP in the FKBP5 gene, is associated with increased risk for bipolar disorder in a study of 500+ Caucasian patients. The most common allele, rs4713902(T), was associated with highest risk. Giving that allele a relative odds ratio of 1.0, the odds for the (C;T) and (C;C) genotypes were 0.69x (CI:0.55-0.88, p=0.001) and 0.47 (CI: 0.30-0.74, p=0.001).

Source and license

Adapted from rs4713902 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.