rs1414334

A SNP in the HTR2C gene on chromosome X. Its most notable genotype is C;C: associated with metabolic syndrome when taking antipsychotics

Gene
HTR2C
Location
Chr X114,903,581 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedassociated with metabolic syndrome when taking antipsychoticsWorth knowing · 2.016% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 16%
  • European ancestry (Utah)C;C 9%
  • Han Chinese (Beijing)C;C 2%
  • Japanese (Tokyo)C;C 2%
  • Yoruba (Nigeria)C;C 43%
  • African ancestry (Southwest US)C;C 28%
  • Chinese (Denver)C;C 0%
  • Gujarati IndianC;C 8%
  • Luhya (Kenya)C;C 36%
  • Mexican ancestry (Los Angeles)C;C 7%
  • Maasai (Kenya)C;C 23%
  • TuscanC;C 13%

Conditions, medicines and genes

Other HTR2C SNPs

All HTR2C SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs1414334(C) associated with the metabolic syndrome in patients using *clozapine (OR, 9.20; 95% CI, 1.95-43.45) *risperidone (OR, 5.35; 95% CI, 1.26-22.83)

C;C

associated with metabolic syndrome when taking antipsychotics and replicated

References

Source and license

Adapted from rs1414334 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.