rs3813929

rs3813929, also known as -759C/T, is a SNP in the 5-hydroxytryptamine (serotonin) receptor 2C HTR2C gene. A study of 107 patients with schizophrenia being treated with olanzapine reported a protective effect against weight-gain from the (T) allele of this SNP; zero patients (of 28) with a rs3813929(T) allele had a body mass index increase of >=10% (p=0.002), whereas (C;C) homozygotes did. This effect may also involve nearby SNP rs518147. T allele showed borderline significant association with higher BMI and incidence of lifetime major depressive disorder among 4978 persons from the European Prospective Investigation into Cancer (EPIC)-Norfolk study, however, only the association with BMI remained borderline significant within the full EPIC-Norfolk cohort (20,981 persons) The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study. Association of the HTR2C gene and antipsychotic induced weight gain: a meta-analysis. The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia. Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression. Focus on HTR2C: A possible suggestion for genetic studies of complex disorders. HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia: a replication study. Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project. Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians. Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction. Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain.