rs141659620

A SNP in the SPG7 gene on chromosome 16. Its most notable genotype is A;A: Spastic paraplegia 7

Gene
SPG7
Location
Chr 1689,531,961 (GRCh38)
Highest magnitude
7.0Very important
Tested on
23andMe, AncestryDNA
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadSpastic paraplegia 7Very important · 7.0
  2. A;GBadUnaffected carrier of a spastic paraplegia 7 mutationImportant · 3.0
  3. G;GGoodcommon in clinvarTypical · 0.0

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other SPG7 SNPs

All SPG7 SNPs

Notes

From SNPedia

Notes

aka c.1045G>A, p.Gly349Ser and G349S Recessively inherited variant associated with spastic paraplegia type 7

A;A

see links via main rs-page

A;G

see links via main rs-page

Source and license

Adapted from rs141659620 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.