rs1467558

A SNP in the CD44 gene on chromosome 11. Its most notable genotype is C;C: common on affy axiom data

Gene
CD44
Location
Chr 1135,208,126 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
8%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon on affy axiom dataTypical · 0.089% of people

SNPedia records rs1467558 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 89%
  • European ancestry (Utah)C;C 65%
  • Han Chinese (Beijing)C;C 100%
  • Japanese (Tokyo)C;C 100%
  • Yoruba (Nigeria)C;C 100%
  • African ancestry (Southwest US)C;C 95%
  • Gujarati IndianC;C 89%
  • Luhya (Kenya)C;C 98%
  • Mexican ancestry (Los Angeles)C;C 81%
  • Maasai (Kenya)C;C 94%
  • TuscanC;C 70%

Conditions, medicines and genes

Other CD44 SNPs

All CD44 SNPs

Notes

From SNPedia

Notes

After taking Acetaminophen (Tylenol®), rs1467558(A;G) individuals have higher alanine aminotransferase (ALT) levels, a sign of liver toxicity, than do (G;G) homozygotes. More studies are needed; there was only 1 (A;A) individual, and he didn't show elevated ALT levels; furthermore, the ALT increases were "modest" anyway for (A;G) individuals compared to (G;G). see also: 23andMe blog Note: the orientation of this SNP in SNPedia is as detailed in dbSNP, but in publications (including 23andMe's blog) the orientation is 'flipped', so what's (A;A) in dbSNP is (T;T) as discussed by the 23andMe blog.

Source and license

Adapted from rs1467558 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.