rs187116

A SNP in the CD44 gene on chromosome 11. Its most notable genotype is G;G: among patients with gastric cancer, risk for more aggressive form?

Gene
CD44
Location
Chr 1135,144,253 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedamong patients with gastric cancer, risk for more aggressive form?Minor · 1.022% of people
  2. A;GNot ratedamong patients with gastric cancer, risk for more aggressive form?Minor · 1.042% of people
  3. A;ANot ratedNo summary available.Typical · 0.036% of people

SNPedia records rs187116 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 22% A;G 42% A;A 36%
  • European ancestry (Utah)G;G 32% A;G 46% A;A 22%
  • Han Chinese (Beijing)G;G 34% A;G 51% A;A 15%
  • Japanese (Tokyo)G;G 45% A;G 37% A;A 18%
  • Yoruba (Nigeria)G;G 1% A;G 20% A;A 78%
  • African ancestry (Southwest US)G;G 5% A;G 39% A;A 56%
  • Chinese (Denver)G;G 37% A;G 45% A;A 18%
  • Gujarati IndianG;G 38% A;G 38% A;A 25%
  • Luhya (Kenya)G;G 2% A;G 31% A;A 67%
  • Mexican ancestry (Los Angeles)G;G 22% A;G 55% A;A 22%
  • Maasai (Kenya)G;G 8% A;G 44% A;A 48%
  • TuscanG;G 23% A;G 53% A;A 25%

Conditions, medicines and genes

Other CD44 SNPs

All CD44 SNPs

Notes

From SNPedia

Notes

rs187116, also known as +4883G>A, is a SNP in the CD44 gene. A presentation at the 2010 American Society of Clinical Oncology meeting based on ~100 patients reported this SNP as being significantly associated with more aggressive gastric cancer. In dbSNP orientation, the risk allele is rs187116(C); patients carrying at least one rs187116(C) had a significantly shorter median time-to-recurrence (TTR) of 2.1 years compared to 7.0 years TTR for rs187116(T;T) patients (p = 0.036, log-rank test).asco.org

Source and license

Adapted from rs187116 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.