rs369473842
A SNP in the CD44 gene on chromosome 11. Its most notable genotype is C;C: IN*B/B Indian Blood Group; possible donor of very rare blood type
- Gene
- CD44
- Location
- Chr 1135,176,644 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableGoodIN*B/B Indian Blood Group; possible donor of very rare blood type
- C;GGoodCarrier of a single IN*A Indian Blood Group allele
- G;GGoodIndian Blood Group IN*B/B
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Notes
From SNPedia
Show notes, about 130 words
Known more commonly as either 252G>C or Arp46Pro (R46P), the rs369473842(C) variant leads to the absence of the Indian B antigen, at least when present in two copies. The absence of the Indian B antigen leads to the IN*A/A phenotype, is generally only observed (rarely) in people of Pakistani, Indian or Iranian descent. One appeal for IN*A/A donors (of blood type O or A) to help a 2 year old child requiring blood transfusions has been posted by OneBlood. In SNP nomenclature, and therefore in Promethease reports, this would be reported as rs369473842(C;C). Note: an incorrect assignment of a different SNP (rs121909545) to this variant is reported in OMIM, ClinVar and some other databases.
C;C
See text on main rs-page.
C;G
See text on main rs-page
G;G
This is by far the most common genotype worldwide.
Source and license
Adapted from rs369473842 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.