rs1734787
A SNP in the MECP2 gene on chromosome X. Its most notable genotype is A;A: normal
- Gene
- MECP2
- Location
- Chr X154,059,995 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 34%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratednormal
- A;CNot rated1.4x increased risk for lupus
- C;CNot rated1.4x increased risk for lupus
On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 53% A;C 16% C;C 30%
- European ancestry (Utah)A;A 75% A;C 10% C;C 15%
- Han Chinese (Beijing)A;A 4% A;C 25% C;C 71%
- Japanese (Tokyo)A;A 19% A;C 16% C;C 66%
- Yoruba (Nigeria)A;A 87% A;C 10% C;C 3%
- African ancestry (Southwest US)A;A 86% A;C 14% C;C 0%
- Chinese (Denver)A;A 7% A;C 16% C;C 77%
- Gujarati IndianA;A 33% A;C 18% C;C 50%
- Luhya (Kenya)A;A 89% A;C 6% C;C 5%
- Mexican ancestry (Los Angeles)A;A 50% A;C 28% C;C 22%
- Maasai (Kenya)A;A 67% A;C 17% C;C 16%
- TuscanA;A 70% A;C 22% C;C 9%
Related
Conditions, medicines and genes
Other MECP2 SNPs
- rs28934904A;GRett Syndrome (predicted)Very important
- rs28934906A;GRett Syndrome (predicted)Very important
- rs28934907A;GRett Syndrome (predicted)Very important
- rs28935468A;GRett Syndrome (predicted)Very important
- rs61748404C;GRett Syndrome (predicted)Very important
- rs61748421A;GRett Syndrome (predicted)Very important
- rs61749721A;GRett Syndrome (predicted)Very important
- rs61750240A;GRett Syndrome (predicted)Very important
Notes
From SNPedia
Notes
rs1734787 is one of several SNPs in the methyl CpG binding protein 2 (MECP2) that have been associated with risk for systemic lupus erythromatosis (SLE). The MECP2 gene is located on the X chromosome, which may be instructive since lupus is a predominantly female disease. An initial survey of 600 Korean patients, followed by 1,000 Caucasian patients, ultimately led to a meta-analysis indicating an odds ratio for the rs1734787(C) risk allele of 1.42 (CI: 1.26–1.60, p = 1.6×10e-08).
Source and license
Adapted from rs1734787 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.