rs28934904
A SNP in the MECP2 gene on chromosome X. Its most notable genotype is A;G: Rett Syndrome (predicted)
- Gene
- MECP2
- Location
- Chr X154,031,431 (GRCh38)
- Highest magnitude
- 8.2Very important
- Tested on
- 23andMe
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;GMost notableBadRett Syndrome (predicted)
- C;CNot ratedNo summary available.
SNPedia records rs28934904 on the minus strand: (C;C), (C;T), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MECP2 SNPs
- rs28934906A;GRett Syndrome (predicted)Very important
- rs28934907A;GRett Syndrome (predicted)Very important
- rs28935468A;GRett Syndrome (predicted)Very important
- rs61748404C;GRett Syndrome (predicted)Very important
- rs61748421A;GRett Syndrome (predicted)Very important
- rs61749721A;GRett Syndrome (predicted)Very important
- rs61750240A;GRett Syndrome (predicted)Very important
- rs61751362A;GRett Syndrome (predicted)Very important
Notes
From SNPedia
Notes
rs28934904, also known as c.397C>T, C397T, p.Arg133Cys and R133C, represents a variant in the MECP2 gene on the X chromosome.
A;G
see rs28934904 and associated links
Source and license
Adapted from rs28934904 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.