rs28934906
A SNP in the MECP2 gene on chromosome X. Its most notable genotype is A;G: Rett Syndrome (predicted)
- Gene
- MECP2
- Location
- Chr X154,031,355 (GRCh38)
- Highest magnitude
- 8.2Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;GMost notableBadRett Syndrome (predicted)
- C;CNot ratedNo summary available.
SNPedia records rs28934906 on the minus strand: (C;C), (C;T), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MECP2 SNPs
- rs28934904A;GRett Syndrome (predicted)Very important
- rs28934907A;GRett Syndrome (predicted)Very important
- rs28935468A;GRett Syndrome (predicted)Very important
- rs61748404C;GRett Syndrome (predicted)Very important
- rs61748421A;GRett Syndrome (predicted)Very important
- rs61749721A;GRett Syndrome (predicted)Very important
- rs61750240A;GRett Syndrome (predicted)Very important
- rs61751362A;GRett Syndrome (predicted)Very important
Notes
From SNPedia
Notes
rs28934906, also known as c.473C>T, C473T, p.Thr158Met and T158M, represents a variant in the MECP2 gene on the X chromosome. The rs28934906(T) allele is reported in RettBASE as the most frequent mutation associated with Rett syndrome. Note that, in contrast to most variants reported in SNPedia, pathogenic MECP2 variants generally arise de novo and are not inherited.
A;G
see rs28934906 and links from that page
Source and license
Adapted from rs28934906 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.