rs1734791
A SNP in the MECP2 gene on chromosome X. Its most notable genotype is A;A: 1.4x increased risk for lupus
- Gene
- MECP2
- Location
- Chr X154,065,469 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 39%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBad1.4x increased risk for lupus
- A;TBad1.4x increased risk for lupus
- T;TNot ratednormal
On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 45% A;T 21% T;T 33%
- European ancestry (Utah)A;A 74% A;T 10% T;T 16%
- Han Chinese (Beijing)A;A 4% A;T 26% T;T 70%
- Japanese (Tokyo)A;A 18% A;T 17% T;T 66%
- Yoruba (Nigeria)A;A 57% A;T 23% T;T 20%
- African ancestry (Southwest US)A;A 67% A;T 30% T;T 4%
- Chinese (Denver)A;A 9% A;T 17% T;T 74%
- Gujarati IndianA;A 35% A;T 20% T;T 45%
- Luhya (Kenya)A;A 66% A;T 19% T;T 15%
- Mexican ancestry (Los Angeles)A;A 48% A;T 29% T;T 22%
- Maasai (Kenya)A;A 50% A;T 25% T;T 26%
- TuscanA;A 70% A;T 21% T;T 9%
Related
Conditions, medicines and genes
Other MECP2 SNPs
- rs28934904A;GRett Syndrome (predicted)Very important
- rs28934906A;GRett Syndrome (predicted)Very important
- rs28934907A;GRett Syndrome (predicted)Very important
- rs28935468A;GRett Syndrome (predicted)Very important
- rs61748404C;GRett Syndrome (predicted)Very important
- rs61748421A;GRett Syndrome (predicted)Very important
- rs61749721A;GRett Syndrome (predicted)Very important
- rs61750240A;GRett Syndrome (predicted)Very important
Notes
From SNPedia
Show notes, about 130 words
rs1734791 is one of several SNPs in the methyl CpG binding protein 2 (MECP2) that have been associated with risk for systemic lupus erythromatosis (SLE). The MECP2 gene is located on the X chromosome, which may be instructive since lupus is a predominantly female disease. An initial survey of 600 Korean patients, followed by 1,000 Caucasian patients, ultimately led to a meta-analysis indicating an odds ratio for the rs1734791(A) risk allele of 1.39 (CI: 1.24–1.57, p = 7.2×10−8). Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations.
Source and license
Adapted from rs1734791 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.