rs1734792
A SNP in the MECP2 gene on chromosome X. Its most notable genotype is A;A: normal
- Gene
- MECP2
- Location
- Chr X154,075,609 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 37%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 32% A;C 20% C;C 48%
- European ancestry (Utah)A;A 16% A;C 10% C;C 74%
- Han Chinese (Beijing)A;A 69% A;C 26% C;C 6%
- Japanese (Tokyo)A;A 66% A;C 16% C;C 19%
- Yoruba (Nigeria)A;A 16% A;C 18% C;C 65%
- African ancestry (Southwest US)A;A 4% A;C 25% C;C 72%
- Chinese (Denver)A;A 73% A;C 16% C;C 11%
- Gujarati IndianA;A 45% A;C 19% C;C 37%
- Luhya (Kenya)A;A 11% A;C 20% C;C 69%
- Mexican ancestry (Los Angeles)A;A 22% A;C 29% C;C 48%
- Maasai (Kenya)A;A 24% A;C 23% C;C 53%
- TuscanA;A 9% A;C 22% C;C 70%
Related
Conditions, medicines and genes
Other MECP2 SNPs
- rs28934904A;GRett Syndrome (predicted)Very important
- rs28934906A;GRett Syndrome (predicted)Very important
- rs28934907A;GRett Syndrome (predicted)Very important
- rs28935468A;GRett Syndrome (predicted)Very important
- rs61748404C;GRett Syndrome (predicted)Very important
- rs61748421A;GRett Syndrome (predicted)Very important
- rs61749721A;GRett Syndrome (predicted)Very important
- rs61750240A;GRett Syndrome (predicted)Very important
Notes
From SNPedia
Notes
rs1734792 is one of several SNPs in the methyl CpG binding protein 2 (MECP2) that have been associated with risk for systemic lupus erythromatosis (SLE). The MECP2 gene is located on the X chromosome, which may be instructive since lupus is a predominantly female disease. An initial survey of 600 Korean patients, followed by 1,000 Caucasian patients, ultimately led to a meta-analysis indicating an odds ratio for the rs1734792(A) risk allele of 1.42 (CI: 1.24-1.58, p = 3.3E-08). Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus.
Source and license
Adapted from rs1734792 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.