rs17435
A SNP in the MECP2 gene on chromosome X. Its most notable genotype is A;T: 1.4x increased risk for lupus
- Gene
- MECP2
- Location
- Chr X154,046,529 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 48%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;ANot ratednormal
- A;TMost notableBad1.4x increased risk for lupus
- T;TBad1.4x increased risk for lupus
On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageA;A 36% A;T 24% T;T 40%
- European ancestry (Utah)A;A 69% A;T 13% T;T 18%
- Han Chinese (Beijing)A;A 7% A;T 24% T;T 69%
- Japanese (Tokyo)A;A 18% A;T 19% T;T 63%
- Yoruba (Nigeria)A;A 24% A;T 19% T;T 58%
- African ancestry (Southwest US)A;A 35% A;T 35% T;T 30%
- Gujarati IndianA;A 33% A;T 21% T;T 46%
- Luhya (Kenya)A;A 33% A;T 29% T;T 38%
- Mexican ancestry (Los Angeles)A;A 43% A;T 29% T;T 28%
- Maasai (Kenya)A;A 35% A;T 28% T;T 37%
- TuscanA;A 64% A;T 23% T;T 13%
Related
Conditions, medicines and genes
Other MECP2 SNPs
- rs28934904A;GRett Syndrome (predicted)Very important
- rs28934906A;GRett Syndrome (predicted)Very important
- rs28934907A;GRett Syndrome (predicted)Very important
- rs28935468A;GRett Syndrome (predicted)Very important
- rs61748404C;GRett Syndrome (predicted)Very important
- rs61748421A;GRett Syndrome (predicted)Very important
- rs61749721A;GRett Syndrome (predicted)Very important
- rs61750240A;GRett Syndrome (predicted)Very important
Notes
From SNPedia
Show notes, about 150 words
rs17435 is one of several SNPs in the methyl CpG binding protein 2 (MECP2) that have been associated with risk for systemic lupus erythromatosis (SLE). The MECP2 gene is located on the X chromosome, which may be instructive since lupus is a predominantly female disease. An initial survey of 600 Korean patients, followed by 1,000 Caucasian patients, ultimately led to a meta-analysis indicating an odds ratio for the rs17435(T) risk allele of 1.39 (CI: 1.24–1.56, p = 1.2×10e-08). Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study. A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations.
Source and license
Adapted from rs17435 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.