rs17595731
A SNP in the TCF4 gene on chromosome 18. Its most notable genotype is C;C: ~20-30x higher risk for Fuchs' dystrophy, a corneal disorder
- Gene
- TCF4
- Location
- Chr 1855,440,221 (GRCh38)
- Highest magnitude
- 2.5Worth knowing
- Tested on
- Not on consumer chips
- Minor allele frequency
- 5%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBad~20-30x higher risk for Fuchs' dystrophy, a corneal disorder
- C;GBad~5 fold higher risk for Fuchs' dystrophy, a corneal disorder
- G;GGoodcommon
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 1% C;G 9% G;G 89%
- European ancestry (Utah)C;C 2% C;G 6% G;G 92%
- Han Chinese (Beijing)C;C 0% C;G 0% G;G 100%
- Japanese (Tokyo)C;C 0% C;G 0% G;G 100%
- Yoruba (Nigeria)C;C 3% C;G 32% G;G 65%
Related
Conditions, medicines and genes
Other TCF4 SNPs
- rs613872G;G~20-30x higher risk for Fuchs' dystrophy, a corneal disorderWorth knowing
- rs9960767C;C1.4x increased risk for schizophreniaMinor
- rs10401120C;Ccommon in complete genomicsTypical
- rs17512836T;Tcommon in complete genomicsTypical
- rs17594526C;Ccommon in complete genomicsTypical
- rs17597926G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs17595731 is a SNP in the transcription factor 4 TCF4 gene. It is one of several TCF4 SNPs reported to be independently associated with Fuchs' dystrophy.
Source and license
Adapted from rs17595731 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.