rs9960767

A SNP in the TCF4 gene on chromosome 18. Its most notable genotype is C;C: 1.4x increased risk for schizophrenia

Gene
TCF4
Location
Chr 1855,487,771 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
9%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormalTypical · 0.073% of people
  2. A;CBad1.2x increased risk for schizophreniaMinor · 1.223% of people
  3. C;CMost notableBad1.4x increased risk for schizophreniaMinor · 1.44% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 73% A;C 23% C;C 4%
  • European ancestry (Utah)A;A 87% A;C 12% C;C <1%
  • Han Chinese (Beijing)A;A 99% A;C <1% C;C 0%
  • Japanese (Tokyo)A;A 100% A;C 0% C;C 0%
  • Yoruba (Nigeria)A;A 55% A;C 37% C;C 8%
  • African ancestry (Southwest US)A;A 64% A;C 34% C;C 2%
  • Gujarati IndianA;A 54% A;C 41% C;C 5%
  • Luhya (Kenya)A;A 51% A;C 39% C;C 10%
  • Mexican ancestry (Los Angeles)A;A 91% A;C 9% C;C 0%
  • Maasai (Kenya)A;A 38% A;C 47% C;C 15%
  • TuscanA;A 91% A;C 7% C;C 2%

Conditions, medicines and genes

Other TCF4 SNPs

All TCF4 SNPs

Notes

From SNPedia

Notes

23andMe blog schizophrenia *rs3131296(C) increased the odds of schizophrenia by 1.19x *rs12807809(T) increased the odds of schizophrenia by 1.15x *rs9960767(C) increased the odds of schizophrenia by 1.23 times.

Source and license

Adapted from rs9960767 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.