rs1800414

A SNP in the OCA2 gene on chromosome 15. Its most notable genotype is T;T: common in complete genomics

Gene
OCA2
Location
Chr 1527,951,891 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
16%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodcommon in complete genomicsTypical · 0.058% of people

SNPedia records rs1800414 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 6 HapMap populations.

  • AverageT;T 58%
  • European ancestry (Utah)T;T 100%
  • Han Chinese (Beijing)T;T 17%
  • Japanese (Tokyo)T;T 17%
  • Yoruba (Nigeria)T;T 100%
  • Chinese (Denver)T;T 17%
  • Gujarati IndianT;T 99%

Other OCA2 SNPs

All OCA2 SNPs

Notes

From SNPedia

Notes

Influences appearance gnxp associated with skin pigmentation in two samples of East Asian ancestry and it confirms previous evidence indicating that evolution towards light skin occurred, at least in part, independently in Europe and East Asia. The OCA2 gene has been under positive selection in Europe and East Asia, but different alleles have been selected in each region. 23andMe blog each rs1800414(C) was associated with a 1.3 melanin unit reduction in skin pigmentation. This SNP accounts for 9% of the variation in skin color seen in the study population.

Source and license

Adapted from rs1800414 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.