rs4778138
A SNP in the OCA2 gene on chromosome 15. Its most notable genotype is A;A: freckles more likely
- Gene
- OCA2
- Location
- Chr 1528,090,674 (GRCh38)
- Highest magnitude
- 1.0Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 45%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 24%
- European ancestry (Utah)A;A 79%
- Han Chinese (Beijing)A;A 9%
- Japanese (Tokyo)A;A 12%
- Yoruba (Nigeria)A;A 5%
- African ancestry (Southwest US)A;A 13%
- Chinese (Denver)A;A 9%
- Gujarati IndianA;A 29%
- Luhya (Kenya)A;A 6%
- Mexican ancestry (Los Angeles)A;A 49%
- Maasai (Kenya)A;A 5%
- TuscanA;A 51%
Related
Other OCA2 SNPs
- rs121918166C;TCarrier of an oculocutaneous Albinism Type II mutationImportant
- rs1800407T;Tgreen/hazel/brown/black eyes more likelyMinor
- rs1800414T;Tcommon in complete genomicsTypical
- rs1800419A;Acommon in clinvarTypical
- rs7495174A;Ablue/gray eyes more likelyTypical
- rs17565841G;Gcommon on affy axiom dataTypical
Genosets
- Gs256carrier for a type of blue eyesWorth knowing
- Gs255Homozygous eye color haplotype #1Worth knowing
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
freckling
Source and license
Adapted from rs4778138 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.