rs1800469(A;G)

Slightly higher TGF-β1 levels, higher risk for COPD?

Magnitude
1.0Minor
Repute
Not rated
Frequency
40%Average of 11 populations
On SNPedia
rs1800469(C;T)Minus strand
Gene
TGFB1

Frequency

Share of people with A;G in each HapMap population.

  • Japanese (Tokyo)50%
  • Mexican ancestry (Los Angeles)50%
  • Han Chinese (Beijing)47%
  • Tuscan45%
  • Gujarati Indian45%
  • Chinese (Denver)41%
  • European ancestry (Utah)36%
  • Yoruba (Nigeria)33%
  • Luhya (Kenya)32%
  • Maasai (Kenya)31%
  • African ancestry (Southwest US)29%

Other genotypes of rs1800469

  1. G;GMost notableNot ratedlower TGF-β1 levels, higher risk for COPD?Minor · 1.045% of people
  2. A;ANot ratedhigher TGF-β1 levelsMinor · 1.015% of people

All about rs1800469

Notes

From SNPedia

The T version, which this (C;T) has one of, increases TGF-β1 levels by preventing AP1 from downregulating TGF-β1 production. But it won't be as high as in the rarer T;T combination.

Source and license

Adapted from rs1800469(C;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.