rs1800469(G;G)

Lower TGF-β1 levels, higher risk for COPD?

Magnitude
1.0Minor
Repute
Not rated
Frequency
45%Average of 11 populations
On SNPedia
rs1800469(C;C)Minus strand
Gene
TGFB1

Frequency

Share of people with G;G in each HapMap population.

  • African ancestry (Southwest US)66%
  • Maasai (Kenya)65%
  • Luhya (Kenya)62%
  • Yoruba (Nigeria)58%
  • European ancestry (Utah)53%
  • Gujarati Indian39%
  • Mexican ancestry (Los Angeles)38%
  • Tuscan37%
  • Han Chinese (Beijing)29%
  • Japanese (Tokyo)29%
  • Chinese (Denver)20%

Other genotypes of rs1800469

  1. A;GNot ratedslightly higher TGF-β1 levels, higher risk for COPD?Minor · 1.040% of people
  2. A;ANot ratedhigher TGF-β1 levelsMinor · 1.015% of people

All about rs1800469

Notes

From SNPedia

This normal C version significantly reduces TGF-β1 levels by allowing AP1 to downregulate TGF-β1 production.

Source and license

Adapted from rs1800469(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.