rs1800471
A SNP in the TGFB1 gene on chromosome 19. Its most notable genotype is C;C: common in clinvar
- Gene
- TGFB1
- Location
- Chr 1941,352,971 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 5%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1800471 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other TGFB1 SNPs
- rs1800469G;Glower TGF-β1 levels, higher risk for COPD?Minor
- rs1800470A;GNo summary available.Typical
- rs1800472G;Gcommon on affy axiom dataTypical
- rs1982073G;Grisk genotype for several disordersTypical
- rs2241715A;Acommon in clinvarTypical
- rs4803455C;Ccommon in clinvarTypical
- rs8110090A;Acommon in complete genomicsTypical
- rs8179181G;Gcommon in clinvarTypical
Notes
From SNPedia
Show notes, about 130 words
rs1800471 encodes a change at codon 25 of the TGFB1 gene. It is reported to predispose several organs to fibrosis, and in relation to Crohn's disease, it was associated with stricturing Crohn's disease (odds ratio 2.63, CI: 1.16-5.88, p=0.01) and a shorter time to intestinal resection (p = 0.06) in a study of several hundred Australian patients. {{PMID Auto |PMID=19258388 |Title=Genetic variation in the transforming growth factor-{beta}1 gene is associated with susceptibility to IgA nephropathy. |OA=1 }} {{PMID Auto |PMID=19380441 |Title=Single Nucleotide Polymorphism at rs1982073:T869C of the TGF{beta}1 Gene Is Associated With the Risk of Radiation Pneumonitis in Patients With Non-Small-Cell Lung Cancer Treated With Definitive Radiotherapy |OA=1 }}
Source and license
Adapted from rs1800471 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.