rs1801195

A SNP in the WRN gene on chromosome 8. Its most notable genotype is G;G: common in clinvar

Gene
WRN
Location
Chr 831,141,764 (GRCh38)
Highest magnitude
0.0Typical
Tested on
AncestryDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in clinvarTypical · 0.023% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 23%
  • European ancestry (Utah)G;G 34%
  • Han Chinese (Beijing)G;G 13%
  • Japanese (Tokyo)G;G 14%
  • Yoruba (Nigeria)G;G 25%
  • African ancestry (Southwest US)G;G 37%
  • Chinese (Denver)G;G 17%
  • Gujarati IndianG;G 36%
  • Luhya (Kenya)G;G 15%
  • Mexican ancestry (Los Angeles)G;G 10%
  • Maasai (Kenya)G;G 17%
  • TuscanG;G 32%

Other WRN SNPs

All WRN SNPs

Notes

From SNPedia

Notes

Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23. A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples. Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM.

Source and license

Adapted from rs1801195 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.