rs113993961

A SNP in the WRN gene on chromosome 8. Its most notable genotype is C;C: Werner syndrome; homozygote for transversion mutation

Gene
WRN
Location
Chr 831,141,680 (GRCh38)
Highest magnitude
6.0Very important
Tested on
AncestryDNA
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadWerner syndrome; homozygote for transversion mutationVery important · 6.0
  2. C;GNot ratedcarrier for Werner syndromeWorth knowing · 2.0
  3. G;GGoodnormalTypical · 0.0

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other WRN SNPs

All WRN SNPs

Notes

From SNPedia

Notes

rs113993961 is a rare transversion in the WRN gene that results in a frameshift of codons 1078 to 1092 due to a change in a splice donor sequence, leading to the recessive disorder known as Werner Syndrome. See OMIM 604611.0004.

Source and license

Adapted from rs113993961 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.