rs17847577

A SNP in the WRN gene on chromosome 8. Its most notable genotype is T;T: Werner's Syndrome

Gene
WRN
Location
Chr 831,081,132 (GRCh38)
Highest magnitude
7.5Very important
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.0
  2. C;TBadUnaffected carrier for Werner's SyndromeVery important · 5.0
  3. T;TMost notableBadWerner's SyndromeVery important · 7.5

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other WRN SNPs

All WRN SNPs

Notes

From SNPedia

Notes

rs17847577, also known as R368X, Arg368Ter, Arg369Ter, c.1105C>T or 1336C>T) represents the most common WRN mutation seen in Caucasians as well as all other non-Japanese populations, perhaps representing ~20% of all Werner Syndrome cases.

Source and license

Adapted from rs17847577 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.