rs193922768
A SNP in the RYR1 gene on chromosome 19. Its most notable genotype is A;C: malignant hyperthermia
- Gene
- RYR1
- Location
- Chr 1938,455,471 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;CMost notableBadmalignant hyperthermia
- C;CGoodcommon in clinvar
- C;TBadmalignant hyperthermia
On SNPedia: (A;C), (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other RYR1 SNPs
- rs118192177C;TMalignant Hyperthermia susceptibilityVery important
- rs146876145C;TMalignant Hyperthermia susceptibilityVery important
- rs28933396A;Aquite likely to have central core diseaseVery important
- rs118192168A;Alikely severe central core diseaseVery important
- rs118192171AC;TTlikely severe central core diseaseVery important
- rs63749869A;Glikely severe central core diseaseVery important
- rs118192169-;TTCTACAACAAGAGCGAGGATlikely severe central core diseaseVery important
- rs193922781C;Tmalignant hyperthermiaVery important
Notes
From SNPedia
Notes
aka c.1597C>A (p.Arg533Ser or R533S) and also c.1597C>T (p.Arg533Cys or R533C) 23andMe name for c.1597C>T: i6017837
A;C
You may be at higher risk for a bad response to anesthetics.
C;T
You may be at higher risk for a bad response to anesthetics.
Source and license
Adapted from rs193922768 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.